Can I use a 4-pack of standard Boveda packets instead of the large Size 320 in my Boveda Humidor?

No. The Boveda Humidor is designed especially for the Boveda Size 320. 

Using this large Boveda in your 50-count humidor maximizes the power of Boveda to ensure a full six months of maintenance-free cigar protection. The continuous use of the Boveda Size 320 via Auto-Replenish is the necessary final link to this complete cigar care system.

Through Auto-Replenish, precise, controlled humidity and zero-lapse cigar protection are managed for you. To access your Auto-Replenish subscription, scan the QR code found on the inside lid of your humidor or click this link.